Large Language Model Evidence Gaps in Clinical Medicine: A Systematic Review Reveals Limited Real-World Validation
An LLM-assisted systematic review of 4,609 clinical studies published between 2022-2025 demonstrates that only 22.7% utilized real-world patient data, with merely 19 prospective randomized trials conducted. The analysis reveals substantial evidence gaps despite rapid proliferation of medical AI research at 3.2 publications per day.